Review Clarks Artisan Suede Slip-on Shoes Daelyn Monarch
Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa)
Selected publications | Contact details | Group members | Collaborations
Graeme Meintjes leads a enquiry plan that focuses on the clinical conditions affecting patients with advanced HIV affliction including disseminated HIV-associated tuberculosis, the tuberculosis-associated allowed reconstitution inflammatory syndrome (TB-IRIS) and cryptococcal meningitis. His group also investigates drug-resistant tuberculosis and diagnostics for TB. He has been the PI or local PI of several clinical trials and conducts observational accomplice studies that address questions related to illness pathogenesis. Recently, he was PI of the EDCTP-funded PredART trial that demonstrated that prednisone was effective and safety for the prevention of TB-IRIS in patients at loftier-gamble starting ART, published in the New England Journal of Medicine in 2018. He has contributed to the development of management guidelines for HIV, TB and cryptococcal meningitis at a provincial and national level and in WHO Guideline Evolution Groups. He is a Member of the Academy of Scientific discipline of S Africa (ASSAf) and the College of Fellows of UCT, and holds a B1 rating from the National Inquiry Foundation. He has been awarded Training (2007), Intermediate (2012) and Senior (2019) Fellowships by the Wellcome Trust. He undertakes clinical work every bit a Specialist at Groote Schuur Hospital and Khayelitsha Hospital, and co-ordinates in the undergraduate teaching plan of the Section of Medicine.
Funding
- Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine. Awarded 2013-2017. Title: "Defining interventions to reduce mortality in severe HIV-associated TB". Role: Personal fellowship.
- South African DST/ National Research Foundation SARChI Chair in Lung Infection and Amnesty in Poverty-Related Diseases at UCT (Grant 64787). Awarded for 4 years (2015-2018).
- Southward African Medical Enquiry Council TB-HIV Collaborating Centre: Clinical and Community HIV-TB Inquiry Collaborating Eye (C2HTB) at UCT. Role: Principal Investigator/Managing director. Awarded for iii years (2015-2017).
- NIH/FIC. 1D71TW009760-01. Championship: HIV associated tuberculosis grooming program. Awarded 2014-2016. Part: Principal Investigator for this planning grant.
- NIH/NIAID. 1R01AI114304-01A1. Title: Prophylactic, pharmacokinetics, and resistance to bedaquiline in XDR TB and HIV. Awarded 2015-2020. Role: South African PI.
- National Enquiry Foundation rating funding awarded in 2013 for 6 years (B2 rating).
Selected publications:
Meintjes G, Stek C, Blumenthal L, Thienemann F, Schutz C, Buyze J, Ravinetto R, van Loen H, Nair A, Jackson A, Colebunders R, Maartens G, Wilkinson RJ, Lynen L; PredART Trial Team. Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS. Due north Engl J Med. 2018 November fifteen;379(xx):1915-1925.
Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John 50, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R; International Network for the Written report of HIV-associated IRIS. Tuberculosis-associated allowed reconstitution inflammatory syndrome: case definitions for utilize in resource-limited settings. Lancet Infect Dis. 2008;viii(viii):516-23.
Meintjes 1000, Wilkinson RJ, Morroni C, Pepper DJ, Rebe 1000, Rangaka MX, Oni T, Maartens G. Randomized placebo-controlled trial of prednisone for paradoxical TB-associated allowed reconstitution inflammatory syndrome. AIDS. 2010;24(15):2381-90.
Meintjes G, Wilkinson KA, Rangaka MX, Skolimowska 1000, van Veen K, Abrahams M, Seldon R, Pepper DJ, Rebe K, Mouton P, van Cutsem G, Nicol MP, Maartens G, Wilkinson RJ. Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome. Am J Respir Crit Intendance Med. 2008;178(10):1083-9.
Lawn SD, Kerkhoff AD, Burton R, Schutz C, van Wyk G, Vogt One thousand, Pahlana P, Nicol MP, Meintjes One thousand. Rapid microbiological screening for tuberculosis in HIV-positive patients on the first day of acute hospital admission by systematic testing of urine samples using Xpert MTB/RIF: a prospective cohort in SA. BMC Med 2015;13:192.
Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek G, Musubire A, Taseera G, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Thienemann F, Lo MW, Nielsen 1000, Bergemann TL, Kambugu A, Manabe YC, Janoff EN, Bohjanen PR, Meintjes Grand; COAT Trial Team. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med. 2014 Jun 26;370(26):2487-98.
Lai RP, Meintjes G, Wilkinson KA, Graham CM, Marais S, Van der Plas H, Deffur A, Schutz C, Bloom C, Munagala I, Anguiano Eastward, Goliath R, Maartens 1000, Banchereau J, Chaussabel D, O'Garra A, Wilkinson RJ. HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Cost-like receptor and inflammasome signalling. Nat Commun. 2015 Sep 24;vi:8451.
Contact details:
Clinical Infectious Diseases Research Initiative
Room WBN 2.09.5
Institute of Infectious Disease and Molecular Medicine
UCT Faculty of Health Sciences
Observatory 7925
Tel: +27 21 406 6075
Fax: +27 21 406 6796
Email: graeme.meintjes@uct.air-conditioning.za
Alternate sites:www.cidri.uct.air conditioning.za
https://www.predart.org/site/index
Group Members:
| Member | Position |
|---|---|
| Amy Ward | Site Managing director HVTN702 |
| Yolisa Sigila | Study nurse HVTN702 |
| Monica Magwayi | Senior Clinical enquiry worker HVTN702 |
| Nobom Masimini | Senior Clinical research worker HVTN702 |
| Amy Nair | Study co-ordinator HVTN702 |
| Phila Mawu | Study co-ordinator HVTN702 |
| Nonceba Gobe | Clinical Research Worker |
| Katlego Mooketsi | Medical laboratory Technologist HVTN702 |
| Loraine Swanepoel | Pharmacist part-time HVTN702 |
| Tania Morar | Chemist part-time HVTN702 |
| Zimasa Gcwabe | Inquiry Nurse HVTN702 |
| Brenda Skonje | Community Liaison Officer HVTN702 |
| Viwe Mgudlwa | Customs Health Worker HVTN702 |
| Owen Vinqishe | Community Health Worker HVTN702 |
| Sakhiwo Tunzi | Community Health Worker HVTN702 |
| Rhandzu Ndzhukule | Report Doctor HVTN702 |
| Nomvula Makade | Secretarial assistant HVTN702 |
| Amanda Jackson | l% Data Systems Manager HVTN702 |
| Mzamo Ntanjane | Information Capturer HVTN702 |
| Meagan McMaster | 50% Data Controller HVTN702 |
| Jolene Bloch | Study Physician HVTN702 |
| Nicola Wills | Report Doctor (Temporary) HVTN702 |
| Erna Kotze | Laboratory Technologist HVTN702 |
| Charlotte Schutz | Senior Medical Research Officer Appetite TRIAL |
| MK Mpalali | Clinical enquiry worker Appetite Trial |
| Siphokazi Hlungulu | Report Co-ordinator Appetite Trial |
| Kyla Comins | Written report Doctor Ambition Trial |
| Primrose Mpangase | Project Manager – PROBeX |
| Nokuthula Maluleka | Research Assistant - PROBeX |
| Liziwe Rwentela | Enquiry Nurse - PROBeX |
| Charlotte Schutz | PhD student |
| Cari Stek | PhD student |
| Sean Wasserman | PhD student |
| Raymond Moseki | PhD student |
| Niel van Hoving | PhD student |
| Janice Peyper (co-supervision) | PhD student |
| Shamila Manie (co-supervising) | PhD educatee |
| Ashar Dhana (co-supervision) | PhD student |
| Rulan Griesel (co-supervision) | PhD educatee |
Collaborations:
Tom Harrison (St George'due south Hospital, London, Uk)
Joseph Jarvis (London School of Tropical Medicine & Hygiene, UK)
David Boulware (University of Minnesota, US)
David Meya (Makerere University, Uganda)
Conrad Muzoora (Mbarara Academy, Republic of uganda)
Anne O'Garra (National Institute of Medical Inquiry, London, United kingdom)
Lut Lynen (Found of Tropical Medicine, Antwerp, Belgium)
James Brust (Albert Einstein College of Medicine, US)
Neel Gandhi (Emory Academy, United states of america)
David Barr (University of Liverpool, U.k.)
* Only collaborators outside UCT are listed
Source: http://www.idm.uct.ac.za/Graeme_Meintjes
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